<I>Influences of surface active agents on hemolysis (2)</I>

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概要

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• The hemolytic activity of 7 compounds of Emulgen series [polyoxyethylen alkyl ether R-0- (CH<SUB>2</SUB>CH<SUB>2</SUB>O<SUB>x) </SUB>H] was tested by the previously described method. 1) It was observed that the more lypophilic the Emulgen, the stronger their hemolytic activity is, and vice versa. 2) Most of Emulgen compounds increased the hemolytic potency of urethane, chloral, HgCl<SUB>2</SUB>, Pb (NO<SUB>3</SUB>) <SUP>2</SUP> and hypotonic solution, but Emulgen 210 inhibited Pb (NO<SUB>3</SUB>) <SUB>2</SUB>hemolysis. 3) The staphylolysin-hemolysis was inhibited by all Emulgen compounds. The ratio of concentration of Emulgen compounds and staphylolysin that suppressed hemolysis was 2C/ C-C/8C (C = the minimum hemolysing concentration). 4) The hemolysis by Emulgen compounds was inhibited by cholesterol, but this was not so strong as in saponin-hemolysis.

• 社団法人 日本薬理学会の論文

著者

• 森川 正利

  長崎大學醫學部藥理學教室

関連論文

• On the influence of surface active agents upon electrokinetic potential (ζ-Potential) of red blood cells
• Influences of surface active agents on hemolysis (1)
• Influences of surface active agents on hemolysis (2)

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