<I>Influences of surface active agents on hemolysis (1)</I>

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概要

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• The hemolytic activity of various surface active agents (SAA) and their influences on the activity of other hemolytic agents was investigated using rabbit red cells. The result : 1) The hemolytic potency of cationic SAA was markedly stronger, than that of anionic or nonionic ones. There seems to be no relation between the hemolytic activity and the surface tension of the SAA solution. 2) Tween 80, G 2162 and Softex KW (cetyl trimethyl ammonium biomide) increased the intensity the hemolysis elicited by urethane, chloral, HgCl<SUB>2</SUB>, Pb(NO<SUB>3</SUB>)<SUB>2</SUB> and hypotonic solution respectively, but Span inhibited it. 3) The hemolytic activity of staphylolysin was suppressed by SAA, especially by cationic agents. The ratio of concentration of SAA and staphylolysin required to suppress hemolysis was C/CC/16C (C= the minimum hemolysing concentration). 4) The hemolytic action of Softex KW and Span 20 was inhibited by cholesterol, but this inhibition was not so strong as in the case of saponin-hemolysis.

• 社団法人 日本薬理学会の論文

著者

• 森川 正利

  長崎大學醫學部藥理學教室

関連論文

• On the influence of surface active agents upon electrokinetic potential (ζ-Potential) of red blood cells
• Influences of surface active agents on hemolysis (1)
• Influences of surface active agents on hemolysis (2)

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