Further studies of pharmacological actions of antihistaminics:(1) Influence of repeated injections of antihistaminics on the mice
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The chronic actions of antihistaminics were studied on the mice, injected daily with Restamin (β-dimethylamino-ethylbenzohydryl-ether-HCl) or Anergen (N-dimethylaminoethylphenothiazine-HCl) for 80-120 days, and the combined actions of antihistaminics and central paralytics or stimulants were observed. The results obtained were as follows : (1) Restamin was found to have excitative and paralytic action on the mice, while Anergen showed only a paralytic action. The acute toxicity of Restamin was stronger on the mice than that of Anergen, but by the chronic toxicity it was reversed. Antagonism of histamine to antihistaminics was observed obscurely on the mice treated with Restamin. (2) The combination of Restamin and the central paralytics increased the sedative action and decreased the Restamin toxicity, while the combination of Restamin and the central stimulants increased the stimulant action. resulting convulsions and the Restamin toxicity. On the contrary, the combination of Anergen and the central paralytics exerted no obvious potentiation in their sedative actions; Anergen was, however, observed antagonistic to the convulsions due to the central stimulants. (3) Antagonism between histamine and Restamin was observed on the isolated intestine of mice treated with Restamin, but not proved, on mice with Anergen. (4) By the experiments. on the tissue respiration the. liver, intestine and. brain of mice injected with Restamin for a short time, became hypersensitive to Restamin, after repeated 80-130 times of injections of Restamin, however, these tissues became hyposensitive. On the contrary, the tissues of the Anergen mice maintained continuously the hypersensitiveness to Anergen. (5) The distribution pattern of Restamin in the bodies of the Restamin mice was observed to be differed from controls.
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関連論文
- Further studies of pharmacological actions of antihistaminics:(1) Influence of repeated injections of antihistaminics on the mice
- Further studies of pharmacological actions of antihistaminics:(2) Pharmacological studies of effect of antihistaminics on the uteri of some animals