Further studies of pharmacological actions of antihistaminics:(2) Pharmacological studies of effect of antihistaminics on the uteri of some animals

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The actions of Restamin (<I>see</I> no. 18 of this <I>Breviaria</I>) and histamine on the isolated uteri of rabbits, gninea pigs and rats were studied and the influences of ovarial hormones thereupon were examined. Result : (1) Histamine showed a stimulating action on the rabbit's and guinea pig's uterus but a paralytic action on the rat's. The paralytic action was not due to the smooth muscle paralysis. (2) Restamin showed an accelerating action on the uterus of rabbit and guinea pig, but in a lower concentration either accelerated or inhibited the motility of the rat's uterus and only suppressed it in a higher concentration. (3) Antagonism between histamine and Restamin was observed on the isolated uterus of rabbit and guinea pig, while not on the rat's uterus. (4) The effect of Ovahormon on the actions of histamine and Restamin was not obvious, while Oophormin controlled the stimulant actions of these two drugs and increased their paralytic actions. (5) Actions of histamine and. Restamin had little to do with the estrus.
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