腫瘍環境応答性の表面物性を有するナノキャリアーの開発

概要

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For achievement of efficient antitumor therapy, we developed novel DDS nano-carriers, which have specific surface properties suitable for in vivo delivery to tumor. In order to avoid interaction with biological components, such as serum protein and reticuloendothelial system, we focused attention on the carriers having negatively charged surface. At first, we constructed negatively charged DDS carrier by tocopheryl succinate (TS), which is known as an anti-tumor vitamin E derivative. The DDS carrier consisting of TS showed potent anti-tumor activity. However, cellular uptake was not enough because of its negatively charged surface. Then, we constructed a novel DDS nano-carrier, which can change surface charge dependent on environmental pH. The novel pH sensitive DDS nano-carrier showed pH-dependent cellular uptake and functionality. Moreover, the nano-carrier accumulated in the tumor like PEG-liposome, although the carrier has no PEG modification to maintain blood circulation time. Consequently, we developed novel DDS nano-carriers having surface functionality responsive to environment in tumor.