血小板膜と脂肪酸との相互作用

概要

論文の詳細を見る
It has been revealed that various fatty acids inhibit platelet functions. Their inhibitory mechanisms were reviewed mainly in the aspect of their alterations of physico-chemical properties of platelet membrane. Among the acids, long-chain cis-unsaturated fatty acids such as linoleic acid increased fluidity of platelet membrane in the concentration ranges where they inhibited aggregation. Their inhibitory effects seem to be at least partly due to their effects in causing membrane perturbation not only in vitro but also in vivo. The relation between membrane fluidity and platelet functions was also discussed. Like unsaturated fatty acids, saturated fatty acids also inhibited platelet aggregation in vitro. They affected maximum aggregation rather than aggregation rate. Their inhibitory effects increased with increase of their alkyl chain length up to C14, whereas from C16 the inhibitory effects tended to decrease with increase of chain length, and stearic acid was not inhibitory. The relation between change in the membrane surface charge by these acids and their inhibitory effects on aggregation was discussed.
日本膜学会の論文