糖輸送 (促通拡散) のインスリンによる調節

スポンサーリンク

概要

• 論文の詳細を見る

• Although mechanisms of insulins regulation of glucose transport is not known, recent advances in biochemistry of insulin receptor and membrane structure and function clarify a certain aspect of transmitting insulins signals. It is recently demonstrated that insulins activation of glucose transport is modified by membrane fluidity, intracellular ATP levels, calcium ion, etc. These possible important factors are discussed individually to give a spectrum of various theories of mechanisms of insulins activation of glucose transport. Through unknown mechanisms, insulin activates glucose transport by increasing <I>V</I>max of transport system rather than changing <I>Km</I>. At present time, it is not clear whether increased transmembrane mobility of glucose carrier or increased available binding sites for glucose contributes to this increased Vmax. Longterm regulation of glucose transport by insulin also relates with change in Vmax. The future investigation on microenvironment of plasma membrane surrounding insulin receptor and transporters seems to be important.

• 日本膜学会の論文

著者

• 小林 正

  滋賀医科大学第三内科

• KOBAYASHI MASASHI

  The Third Department of Medicine, Shiga University of Medical Science

関連論文

• レセプター
• Effect of Acute Exercise on Insulin Binding to Erythrocytes in Type II Diabetes
• Evaluation of the Method of Insulin Binding Studies in Human Erythrocytes
• Effect of Age and Sex on Insulin Binding to Human Erythrocytes
• 糖輸送 (促通拡散) のインスリンによる調節
• Familial Spinal Xanthomatosis with Sitosterolemia.
• Leprechaunism:インスリンレセプター異常による著明なインスリン抵抗性を示した女児例

スポンサーリンク