Evaluation of the Method of Insulin Binding Studies in Human Erythrocytes
スポンサーリンク
概要
- 論文の詳細を見る
A modified erythrocyte insulin receptor assay was developed. The major advantage of our method is the smaller amount of blood necessary for the assay and consequent simple handling in the binding assay. Three m<I>l</I> of blood is enough for this assay, making it possible to assess insulin receptors in a group of pediatric patientts. There was a close relationship between mononuclear cells and erythrocyte insulin binding assays (r=0.900, p<0.05).<BR>With this method insulin binding studies were done on normal subjects and adult onset non-obese diabetics. Decreased insulin binding was seen in the diabetic group, and this was due to a decreased number of insulin receptors.<BR>This erythrocyte insulin receptor assay can be a useful tool for the study of the mechanism of insulin resistance.
- 社団法人 日本内分泌学会の論文
著者
-
Maegawa Hiroshi
The Third Department Of Medicine Shiga University Of Medical Science
-
小林 正
滋賀医科大学第三内科
-
SHIGETA YUKIO
The Third Department of Medicine, Shiga University of Medical Science
-
IWASAKI MAKOTO
The Third Department of Medicine, Shiga University of Medical Science
-
KOBAYASHI MASASHI
The Third Department of Medicine, Shiga University of Medical Science
-
OHGAKU SEIJI
The Third Department of Medicine, Shiga University of Medical Science
-
HARANO YUTAKA
The Third Department of Medicine, Shiga University of Medical Science
関連論文
- Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
- High Glucose Condition Desensitizes Insulin Action at the Levels of Receptor Kinase
- Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
- Membrane Localization of Protein-Tyrosine Phosphatase 1B is Essential for its Activation of Sterol Regulatory Element-Binding Protein-1 Gene Expression and Consequent Hypertriglyceridaemia
- Short-term Low-dosage Pioglitazone Treatment Improves Vascular Dysfunction in Patients with Type 2 Diabetes
- Protein-Tyrosine Phosphatase 1B Associates with Insulin Receptor and Negatively Regulates Insulin Signaling without Receptor Internalization
- Evaluation of a New Care System Provided to Diabetic Patients in the Outpatient Clinic
- Opposite Regulation of Tyrosine-Phosphorylation of p130^ by Insulin and Insulin-Like Growth Factor I
- High Glucose-Induced Abnormal Epidermal Growth Factor Signaling^1
- β-Sitosterolemia with Generalized Eruptive Xanthomatosis
- レセプター
- The Onset of Diabetes in Three out of Four Sisters : A Japanese Family with Type 1 Diabetes, A Case Report
- Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes
- Effect of Propranolol on Glucose Disposal Rate in Patients with Hyperthyroidism
- Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy : effects of miglitol
- Effect of Acute Exercise on Insulin Binding to Erythrocytes in Type II Diabetes
- Evaluation of the Method of Insulin Binding Studies in Human Erythrocytes
- The role of sleep disturbance and depression in patients with type 2 diabetes
- Laparoscopic sleeve gastrectomy leads to rapid improvement of glucose tolerance and insulin secretion with enhanced glucagon-like peptide (GLP-1) secretion
- Effects of hyperglycemia on oxidative stress and antioxidant potential in patients with type 2 diabetes
- Effect of Age and Sex on Insulin Binding to Human Erythrocytes
- 糖輸送 (促通拡散) のインスリンによる調節
- Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association
- Familial Spinal Xanthomatosis with Sitosterolemia.
- Leprechaunism:インスリンレセプター異常による著明なインスリン抵抗性を示した女児例