EXPERIMENTAL STUDIES ON THE EFFECT OF SO-CALLED SECONDARY ANTITUBERCULOSIS DRUGS (2)
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The following two experiments were carried out to study 1) the difference in therapeutic effects between the combined regimens with primary antituberculosis drugs and those with secondary drugs, and 2) single and conbination effects of secondary drugs. Experiment 1: Young CF<SUB>1</SUB> male mice, intravenously infected with H<SUB>37</SUB>Rv (v. u. 3.6×10<SUP>5</SUP>) and left untreated for 3 weeks, were divided into 12 groups; SM, KM, INH, TH, SM·INH, KM·TH, SN·INH·PAS, SM·INH·ISOXYL, KM·TH·CS, KM·TH·ISOXYL, KM·TH·SF, and untreated control. After the treatment with these drugs for 7 weeks, they were necropsied at the end of each chemotherapy. SM 20mg/kg and KM 40mg/kg were administered twice weekly subcutaneously, and INH 4mg/kg, TH 12mg/kg, PAS 200mg/kg, ISOXYL 100mg/kg, CS 10mg/kg and SF (Sulfisoxazole) 40mg/kg orally once daily for six days weekly. Each mouse was examined for body weight, macroscopic changes of lung lesions, lung weight and the average number of viable tubercle bacilli in the lung at necropsy.<BR>Results: 1. Combination effect of primary antituberculosis drugs containing INH on experimental tuberculosis in mice was due mainly to the effect of the administration of INH daily, and similarly combination effect of secondary drugs containing TH was due mainly to that of TH daily. Combination effect of secondary drugs containing TH was distinct, but much inferior to the effect of primary drugs containing INH.<BR>2. Effects of SM semi-weekly and KM semi-weekly were found to be the same and found. to be much inferior to the effect of TH daily.<BR>3. Any effect of SM semi-weekly, KM semi-weekly, PAS daily, ISOXYL daily, CS daily, , and SF daily, when added to INH daily or TH daily, was not observed. Experiment 2: Young ddY female mice, infected with H<SUP>37</SUP>Rv (v. u. 1.5×106) which had been preserved by the freeze-drying method since 1957, and left untreated for 2 weeks, were divided into 12 groups: -KM, TH, CS, PZA, KM·CS, KM·TH, TH·CS, KM·TH·CS, KM·TH·PZA, KM. CS. PZA, TH·CS·PZA and untreated control. They were necropsied at the end of each chemotherapy for 5.5 weeks. PZA 40mg/kg was administered six times weekly orally, and the other three drugs were given as previously mentioned. Each mouse which was killed at necropsy or died of lung tuberculosis during the treatment was examined for body weight, macroscopic changes in lung lesions, lung weight and amount of viable tubercle bacilli in the lung.<BR>Results: 1. Marked therapeutic effects were observed in the groups treated with TH alone and also in the groups treated with TH in combination with other secondary drugs, but the difference among those groups was not found.<BR>2. Effects of KM semi-weekly and CS daily were almost the same, and both were inferior to that of TH daily. Combined therapy of KM and CS was slightly more effective than single drug regimen.<BR>3. PZA was not effective in single regimen; it did not show any increase in the effectiveness of the companion drug.
- 一般社団法人 日本結核病学会の論文
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関連論文
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