サルコイド-ジスの臨床的研究-1-自験167例の検討
スポンサーリンク
概要
- 論文の詳細を見る
Between 1962 and 1979, one hundred and sixty-seven patients with sarcoidosis were seen at our clinic, 59 were male and 108 were female, with ages ranging from 11 to 73 years. The clinical findings in our patients were compared with those of other series from the literatures, mainly of Japanese Sarcoidosis Committee.<BR>1. In our series, 71 patients (42.5%) were detected by the mass miniature radiography. In patients detected by symptomatic visit, 52 patients (31.1%) complained ocular symptoms and others complained one or more symptoms such as fatigue, fever, pulmonary signs (cough and/or sputum), and joint pain.<BR>2. As it is difficult to diagnose sarcoidosis only by the chest roentgenograms, we performed some kinds of biopsy procedures for diagnosing sarcoidosis. A total of 232 tissue specimens had been obtained from 158 patients, and epitheloid cell granulomas were found in 61.8% of specimens. When ocular involvements were the only demonstrable abnormality of the disease or no hilar adenopathy was seen, a mediastinoscopic biopsy should be done, and this will be useful in making the differential diagnosis of the sarcoidosis.<BR>3. Serum angiotensin. I converting enzyme (ACE) level was found to be significantly elevated in patients with active sarcoidosis (46.5±13.1unit), compared to that of patients with inactive sarcoidosis (20.0±7.1unit) and normal control subjects (20.9±7.1 unit).<BR>In 14 patients with bilateral hilar adenopathy, initial serum ACE activity was 40.1±12.9 unit and it dropped down to 26.5±10.5 unit after the disappearance of hilar adenopathy, and the difference was highly significant.<BR>4. A number of factors were found to be useful in predicting the prognosis of sarcoidosis. Generally speaking, the resolution of nearly all types of sarcoidosis lesions are expected within two years after the diagnosis was made. The factors which relate to good prognosis were the male patients diagnosed by the mass miniature radiography, the age below 28 and the absence of ocular involvements. The prognosis of the patients with acute onset were very good.
- 一般社団法人 日本結核病学会の論文
一般社団法人 日本結核病学会 | 論文
- 秋田県龜田町の結核実態調査-2-
- 秋田県龜田町の結核実態調査-1-
- 非定型抗酸菌排出者の臨床
- 正常人T細胞のE-rosette形成能に及ぼす肺結核患者血清の抑制作用
- 結核病巣内のmononuclear phagocytesの酵素活性,特にβ-galactosidaseおよびnaphthol AS-D acetate esteraseの変動