Studies on the Types of Chemotherapy in Pulmonary Tuberculosis:Report 3. Chemotherapy of patients with far advanced pulmonary tuberculosis and resistant tubercle bacilli

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It is very important to know the best combination of chemotherapeutic agents to chronic resistant far advanced pulmonary tuberculosis. We compared the results of the following 7 types of chemotherapy in the treatment of 74 patients of far advanced pulmonary tuberculosis with resistant tubercle bacilli. i) INH single therapy…6 cases ii) INH-PAS therapy…7 cases iii) INH-PZA therapy…9 cases iv) SM-PAS-INH therapy…18 cases v) SM-PAS-INH-Sulfadrug therapy …14 cases vi) SM-PAS-INH-PZA therapy…9 cases vii) INH-PZA-Sulfadrug therapy…11 cases The results were observed for 3 to 6 months. Generally speaking, two drug combination therapy is better than one drug single therapy, three drug combination therapy is better than two drug combination therapy, and four drug combination therapy is better than three drug combination therapy. Since most of the patients had SM-, PAS-, or INH-resistant tubercle bacilli, four drug combination therapy is not so effective as expected. Sulfadrug, PZA…to which the tubercle bacilli of the patients were not resistant…and INH combination therapy is the most effective among these 7 types of therapy, but the complications were most frequently observed in this type. Consequently, we considered that new types of combination of newer antituberculous drugs (KM, CS, 1314TH etc.) should be surveyed.
一般社団法人日本結核病学会の論文