肺結核治療におけるRFP併用例とRFP非併用例の治療開始より5年間の経過の比較

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概要

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• In 1976, we reported a paper under the title of “Comparison of the effects between combined chemotherapy with and without rifampicin (RFP) in original and retreatment of pulmonary tuber culosis with special reference to the grade of improvement of chest X-ray findings” (Kekkaku, 51: 353, 1976), and concluded that the grade of improvement on chest radiogram in RFP group and non-RFP group was similar, although the improvement was seen faster in RFP group than in non-RFP group, and accordingly, a marked shortening of the duration of chemotherapy in chronic pulmonary tuber culosis could not be expected even though a regimen including RFP might be stronger than another combination without RFP.<BR>The above conclusion was obtained from two years observation after starting treatment, and we continued follow-up for another three years (total five years), exchanging some inadequate cases for another adequate cases, and investigated whether there is any difference between the course of the RFP group and non-RFP groups.<BR>In the present study, we added further a new group to the original treatment cases: that is, a group who started treatment with regimens not containing RFP and then seven months or later from the start of therapy RFP was used supplementarily (RFP supplemented group). Tubercle bacilli in sputum converted negative in nearly all cases, and there was no significant difference in the results among groups treated with different regimen.<BR>On chest radiogram, a little surpassing improvement was observed in RFP group of original treat ment as compared with other groups, though background factors might be rather favourable in RFP group. This exceeding improvement of RFP group became clearer when putting together all the data obtained from “Standard for the evaluation of X-ray findings including basic lesion & cavities”, “Standard for the summarized evaluation of response to chemotherapy of pulmonary tuberculosis” and “Standard of the attainment of therapeutic targets” (Gakken).<BR>On the contrary, the results both in RFP supplemented group and RFP retreated group was not so good as that in RFP group of original treatment.<BR>As mentioned above, the grade of improvement was more complete in the RFP group of original treatment than in the non-RFP group of retreatment, but we could not reach a conclusion from this study whether the shortening of the duration of chemotherapy in chronic pulmonary tuberculosis is possible or not by adding RFP.

著者

• 井上 満

  国立療養所東埼玉病院

• 吉田 文香

  埼玉県立小原療養所

• 小川 辰次

  浦和市立病院

• 吉田 六郎

  埼玉県立寄居保養所

• 石井 晃

  積仁会旭丘病院

• 吉村 正也

  国立療養所東埼玉病院

• 松宮 恒夫

  埼玉県立小原療養所

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