結核菌体成分による組織反応(第44回日本結核病学会総会特別講演)
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In consideration of the mechanism of formation of epithelioid granuloma, which is histologically characteristic of tuberculous lesions and some other diseases, a new category of allergic reactions, a superdelayed type of allergy, was proposed by this author at the Autumnal General Meeting of the Japanese Pathological Society in 1960 (Acta_ Path. Jap.10: 419). At that time it was reported that in only tuberculo-sensitized animals (rabbits and guinea pigs) an Arthus type of necrotizing lesion was induced by tuberculopolysaccharide fractions and a tuberculin type of monocytic granulation by tuberculo-protein fractions from tubercle bacilli some days after the pulmonary instillation of these fractions. In contrast to these early reactions, epithelioid granulomas were produced in the treated lungs of sensitized animals some weeks after the administration of bacterial lipoids; for example, Choucroun's sensitizing material, Yamamura's lipoprotein, Anderson's phosphatide A3, and Lederer's wax D. Therefore, the granulomaproducing reactions to these antigens were named "superdelayed type" because of the markedly delayed appearance of tissue reactions. In control animals, these lipoids also induced epithelioid granulomas two to three weeks later than in sensitized animals. This shows the ability of these fractions to sensitize treated animals with an interval of a couple of weeks. In any case, it was pointed out that epithelioid granuloma is induced by superdelayed allergic reaction to some lipoidal components of tubercle bacilli or related bacteria in sensitized animals.
- 一般社団法人 日本結核病学会の論文
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- 結核菌体成分による組織反応(第44回日本結核病学会総会特別講演)