肺結核初回治療におけるSM・EB・INH併用療法の評価第1報臨床例におけるSM・EB・INHとSM・PAS・INH治療の比較
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A study was made to intensify the clinical effects of initial chemotherapy for pulmonary tuberculosis. Since side effects of PAS such as gastrointestinal disturbance and allergic reaction are frequently seen, and its anti-tuberculous effect in vivo is less than that in vitro, a trial was made to substitute PAS by EB as one of the primary drugs in the initial combined treatment with SM and INH.<BR>One hundre d and thirty patients with newly found active pulmonary tuberculosis were devided at random into two groups; 66 cases treated with SM, INH and EB (Group I) and 64 cases treated with SM, INH and PAS (Group II). The dose of the drugs was as follows: 1 gm SM per day twice a week, 400 mg INH divided in two doses daily, 10 gm PAS divided in four doses daily and 1 gm EB daily.<BR>No significant difference wa s found in the background factors of patients before starting chemotherapy between both groups, and the details are presented in Fig.1. The sputum positivity was 48.4% in group I and 26.5% in group II by smear, and about 70% in both groups by culture.<BR>Roentgenographic examinations of the chest by routine PA films and tomograms were made in each case before and every month after starting treatment. Bacteriologic examinations were done every month for three consecutive days with sputum or specimens collected by gastric lavage if sputum was not available. Clinical signs and symptoms were checked monthly in respect of body weight, temperature, erythrocyte sedimentation rate, cough, sputum and appetite.<BR>During the treatment, all the cases were subjected to laboratory examinations once or twice a month to detect any toxic side effect of drugs on liver, kidney, eye and other organs by means of hematologic examinations, liver function test by protein fractionation, routine test of urine and faeces. In addition to these tests, ophthalmologic examinations including determination of visual acuity, visual field, color vision and fundscopy were conducted for patients in group I
- 日本結核病学会の論文
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- 肺結核初回治療におけるSM・EB・INH併翔療法の評価 : 第2報実験結核症におけるSM・EB・INHとSM・PAS・INH組合せによる効果の比較
- 肺結核初回治療におけるSM・EB・INH併用療法の評価第1報臨床例におけるSM・EB・INHとSM・PAS・INH治療の比較