ツベルクリンアレルギ-に関する研究-1-ツベルクリン反応発現に関与する感作細胞の機能と皮内反応部位の浸潤細胞との相関関係について
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There are two types of cell populations which mediate the tuberculin hypersensitivity: sensi-tized T lymphocytes and non-specific accessory cells. The present study was undertaken to eluci-date the identity of cells which can transfer tuberculin hypersensitivity, those which produce the macrophage migration inhibitory factor (MIF), and those which produce the leucocyte migration inhibitory factor (LIF). In addition, it was studied that the relation between the MIF or LIF producibilities of transferred sensitized cells and the composition of infiltrating cells in the skin reaction site in normal (non-irradiated) or irradiated (800 rad) recipients.<BR>The results were as follows:<BR>1. The ability of tuberculin-type hypersensitivity (TTH) transfer, MIF production and LIF production were equally prominent in the regional lymph node cells of guinea pigs vaccinated (V group) with heat-killed BCG.<BR>2. The ability of TTH transfer and LIF production were prominent, but MIF production was not detected in the spleen cells of the V group.<BR>3. The ability of TTH transfer and MIF production was detected in the regional lymph node cells of guinea pigs vaccinated and challenged (VC group) with heat-killed BCG, but that ability was weaker than that of regional lymph node cells of the V group. Leucocyte migration stimula-ting activity was observed in the regional lymph node cells of the VC group, but LIF production was not seen there.<BR>4. The ability of TTH transfer was most dominant in the spleen cells of the VC group. MIF production was also detected in the spleen cells, and was equal to that of the regional lymph node cells of the VC group. Leucocyte migration stimulating activity, but not LIF production, was observed in the spleen cells of the VC group, as was the case in the regional lymph node cells of the VC group.<BR>5. In the skin lesions of the PPD test on, normal or <SUP>60</SUP>Co-irradiated (800 rad) recipients, the number of infiltrating non-specific accessory cells, i. e., mononuclear cells or polymorphonuclear leucocytes, was not histopathologically parallel with the MIF or LIF producibilities of transferred sensitized regional lymph node cells or spleen cells of the V group.<BR>6. The PPD-skin lesions of <SUP>60</SUP>Co-irradiated (800 rad) recipients were macroscopically more prominent than those of normal (non-irradiated) recipients transferred with sensitized regional lymph node cells or with spleen cells of the V group. However, the total number of infiltrating cells in the skin lesions of irradiated recipients decreased to about half of the number in those of normal (non-irradiated) recipients.<BR>It was concluded that the ability of TTH transfer <I>in vivo</I> and the ability of MIF production <I>in vitro</I> are not always parallel, and that the ability of TTH transfer <I>in vivo</I> is parallel with the ability of each of LIF or leucocyte migration stimulating factor production <I>in vitro</I>, and that the total number of infiltrating cells in skin reaction site was not always correlated with the size of the skin reaction, but the number of infiltrating cells in the skin reaction site was strongly con-trolled by the total number of mobile cells in each animals.
- 一般社団法人 日本結核病学会の論文
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