BCG接種群でのツベルクリン反応の「判定」について

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The distribution by size of tuberculin reactions was studied in previously BCG-vaccinated school children by three tuberculin examinations successively made with one year interval without giving re-vaccinations, to find that the distribution was always unimodal and symmetric, to be approximated by a normal distribution, and that each fraction of the distribution showed again a normal distribution in the next examination, spreading its skirts far beyond its initial range of size, reflecting a fairly large fluctuation of each individual's reaction size.<BR>It is concluded from the findings that, tallying with findings reported from the WHO, the classification of tuberculin reactions by size into "positive" and "negative" cannot logically be applied in BCG-vaccinated populations, and that the post-vaccination allergy level is expressed best, not by the "positive conversion rate", but by the mean size and the standard deviation, indicating the overall distribution of tuberculin reactions. Considering the duration of BCG vaccination effect expressed by the tuberculin allergy level, which must be much longer than used to be estimated before by accumulating the number of "negative reverters", and also the illogicality of the present screening method for revaccination by the "positive"-"negative" classification of tuberculin reactions, a need for re-examining the method and the necessity of the BCG re-vaccination is stressed.
一般社団法人日本結核病学会の論文

BCG接種群でのツベルクリン反応の「判定」について

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