Tuberactinomycin-Nによる肺結核治療の臨床的研究

概要

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Tuberactinomycin-N (TUM-N) is a peptide antibiotic which has been isolated from the culture filtrate of <I>streptomyces griseoverticillatus var. tuberacticus N6-130</I>. This antibiotic is principally effective against tubercle bacilli and the activity is proved to be almost same as that of viomycin. The cross-resistance is observed between TUM-N and viomycin or capreomycin, however, only one way cross resistance is shown with kanamycin, and TUM-N is effective against kanamycin-resistant bacilli.<BR>In the present study, authors have observed the therapeutic effect and the side effects of TUM-N in 88 patients of severe pulmonary tuberculosis with cavities, who were sensitive to viomycin. The duration of TUM-N treatment has been fixed for six months and the antibiotic was administered by intramuscular injections at the dose of 1 gram once daily for the first three months and twice weekly thereafter combined with other antituberculous drugs which had been used orally just prior to TUM-N treatment.
日本結核病学会の論文