抗酸菌バクテリオシンに関する研究 : 1)マイコバクテリオシン検出に及ぼすクロロホルムその他の有機溶媒の影響

概要

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Mycobacteriocin produced by <I>Mycobacterium fortuitum</I> ATCC 6841 was detected only when the bacilli on the assay plate were treated with chloroform, whereas no bacteriocin activity was observed in the non-treated plate. Carbon tetrachloride, ethyl ether, benzen, 1, 2-dichloroethane, petroleum ether and aceton had similar effects to that of chloroform. The treatment with chloroform resulted in the complete killing of the bacilli, but other organic solvents tested had no killing effect. Therefore, the mycobacteriocin which was detected by chloroform treatment might not be due to the extraction of the active principle from bacterial cells after death.<BR>On the other hand, in the control experiments with colicin, such effects o f the organic solvents were not demonstrated, and colicin was detected either when the plate was treated with or without chloroform.<BR>Mycobacteriocin, which showes its activity just after the treatment of chloroform, is quite distinct from colicin and other bacteriocin previously been reported in the literatures.
日本結核病学会の論文