同種可溶性肺抗原投与によるマウス肺病変に関する研究

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Recently, some pulmonary diseases such as sarcoidosis, Hamman-Richs syndrome and Good pastures syndrome are thought to be caused by immunological reactions. As to animal models of these diseases, there are many reports on pulmonary lesions induced by lung antigen.<BR>In this study, allogeneic soluble antigen was injected to mice subcutaneously and the lung tissue was studied by light microscopy and electron microscopy.<BR>Allogeneic soluble lung antigen was shown to be capable of producing pulmonary lesions in mice following subcutaneous injection. The pulmonary lesions were consisted of the followings; a) peribronchial and perivascular plasma cell aggregation; b) numerous macrophage infiltration into the alveolar space; c) swelling and proliferation of granular pneumocytes following intravenous booster injection.<BR>The immunological pathogenesis was suggested by the demonstration of antibody in the sera to allogeneic soluble antigen by hemagglutination test.<BR>The serum angiotensin I converting enzyme (ACE) activity was also tested. The injection of allogeneic soluble lung antigen caused significantly high serum ACE level compared with that of normal controls, and it was suggested that the high level of serum ACE was due to proliferation of macrophages in the alveolar space
日本結核病学会の論文