タイトル無し
スポンサーリンク
概要
- 論文の詳細を見る
In vitro combined effect of minocycline with various antituberculous drugs on the growth of Mycobacterium tuberculosis strain H37Rv was studied. The concentrations of antituber culous agents used were those, except for isoniazid (INH) and kanamycin sulfate (KM), retarding the growth rate of the test organism (Tsukamura, M., and Mizuno, S.: Kekkaku 55: 365-370, 1980) but permitting the colony formation from a diluted bacterial suspension (Table 1). The effect of INH on the growth of M. tuberculosis was an "all or none" -type (see above reference), and therefore the concentrations of INH used in this study did not affect the growth of the organism when used singly. The concentrations of KM used were too low to affect the growth rate. The concentrations of the other drugs retarded more or less the growth rate, but such concentrations did not inhibit the formation of colonies from single cells.<BR>In the present study, it has been observed how the combined antituberculous agents could modify the growth-inhibitory concentration of minocycline. The results are shown in Table 1.<BR>The inhibitory action of minocycline was weakened in the presence of ethionamide (TH), INH and KM, whereas it was enhanced by the presence of enviomycin (EVM), ethambutol (EB) and para-aminosalicylate (PAS). The inhibitory concentration of minocycline remained un changed in the presence of streptomycin sulfate (SM), rifampicin (RFP) and cycloserine (CS).<BR>The results indicated that minocycline and TH, or minocycline and INH act antagonisti cally and that minocycline acts synergistically or at least additionally with EB, EVM, and PAS
- 一般社団法人 日本結核病学会の論文
一般社団法人 日本結核病学会 | 論文
- 秋田県龜田町の結核実態調査-2-
- 秋田県龜田町の結核実態調査-1-
- 非定型抗酸菌排出者の臨床
- 正常人T細胞のE-rosette形成能に及ぼす肺結核患者血清の抑制作用
- 結核病巣内のmononuclear phagocytesの酵素活性,特にβ-galactosidaseおよびnaphthol AS-D acetate esteraseの変動