移植癌に対する組織内マクロファ-ジの動態

概要

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In the rabbits transplanted intradermally with Brown Pearse sarcoma cells (B-P cells), the mononuclear cell turnover in the skin lesions was studied periodically. The mononuclear cells (MNs), that were positive for β-galactosidase, made defense walls in the periphery of the tumor lesions from 4 to 16 days after B-P cells transplantation. During the days, the intradermal growth of B-P cells was enhanced more prominently in the rabbits with BCG inoculation on the day of the tumor transplantation than in the rabbits without BCG inoculation, while thereafter, the defense walls of the MNs became gradually loose and then disappeared in both groups.<BR>Thereupon, a number of the MNs in 1 mm<SUP>2</SUP> of the peripheral lesion was counted periodically. The accumulation of the MNs in a tumor lesion of the rabbits without BCG lesions at the 7th day was about 2 fold higher than that with BCG lesions.<BR>These results suggest that the MNs have a inhibitory capacity depending on a number of the accumulated MNs in the tumor lesions, and the inhibitory capacity of the MNs is reduced if the supply of the MNs is divided into the BCG lesions and the tumor lesions, thus causes the enhanced tumor growth.