エンビオマイシン過敏症の脱感作療法の1例

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This is a report on a case of the treatment of a pneumoconio tuberculous patient (64 years old, male) with Enviomycin (EVM). This patient had hypersensitivity to many drugs, but after success of desensitization to EVM, he has shown good progress.<BR>The patient had been treated with SM after the successful desensitization to SM, but he produced resistance to SM and the decision was made to change the drug. At first, hypersen sitivity to EVM was confirmed by skin test and the result was positive and then the desensitiza tion to EVM was carried out. The procedure was started with one hundredths (10mg) of the usual dose and every 3-4days the dose was increased by 1/2-2 times of the previous dose.<BR>Although such increase of dose was continued until reaching 500mg on the 38th day, no hypersensitivity was observed. After this procedure, 1g a day EVM was administered daily intramuscularly and at present the chemotherapy with the dose of 2g a day twice a week is being continue<BR>As a result, the sputum converted to negative both on smear and culture and the patient has shown good progress.
一般社団法人日本結核病学会の論文