Nitrofuran誘導体の試験管内結核菌発育阻止作用について

概要

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Nine nitrofuran derivatives, 2-(5-nitro)-furylacryl niethylalcohol (No.1), 2-(5-nitro)-furylacrolein (No.2), 2- (5-nitro)-furylacrolein semicarbazone (Parafuracine) (No.3), 2-(5-nitro)- furylacrolein 4- Phenylseraicarbazone (No.4), 2-(5-nitro)-furylacrolein 4-phenetbylsemicarbazone (No.5), 2-(5-nitro)- furylacrolein thiosemicarbazone (No.6), 2-(5-nitro)-furylacrolein aminoguanidine hydrochloride (No.7), 4-(2-(5-nitro)furfulydine)-4-caploylamino-1, 1-diphenylsulfone (No.8), 2-(5-nitro)-furfural-2-butoxy5-aminopyridine (No.9), and three pyridine derivatives, 2-butoxy-5-aiuinopyridine hydrochloride (No.10), 2-amino-3-nitropyridine hydrochloride (No.11), 2-amino-5-nitropyridine hydrochloride (No.12) were examined of their bacteriostatic effect against Mycobacterium tuberculosis hominis Aoyama B strain in vitro. The medium used was Kirchners serum medium and the amount of tubercle bacilli inoculated was 10<SUP>-3</SUP>mg per tube.
日本結核病学会の論文