PASSIVE TRANSFER OF IMMUNITY TO TUBERCULOSIS BY MEANS OF CELLS FROM BCG VACCINATED MICE:II. Effects of Various Pretreatments of Cells to be Transferred

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It was reported in the previous report that an antimicrobial activity against a virulent strain of <I>M. tuberculosis</I> could be conferred to dd mice, when they were transferred with peritoneal cells derived from the homologous (dd) mice which had been immuni zed with BCG strain. This effect of passive transfer was already apparent when the recipients were challenged 4 days after the transfer. In the present report the effects of some pretreatments of cells to be transferred and streptomycin (SM) administration to recipient mice after transfer were investigated. The results were judged by counting viable units of tubercle bacilli in the spleen and lung at various intervals after the challenge with a virulent strain resistant to SM, the culture being performed on media with and without SM.<BR>A similar effect of passive transfer as by intact cells was obtained by using the material which had been oscillated (10 kc) for 2.5 minutes, but not by cells heated at 48°C 30 minutes. Viable units in organs of mice transferred with the heated cells showed the numbers similar to those in control animals. The effect of passive transfer with intact cells was also almost nullified when SM was administered during 4 days from immediately after transfer until challenge.<BR>It was assumed from previous experiments that viable cells of BCG contained in transferred cells of immunized mice could withstand the pretreatments of heating or oscillation mentioned above, but they may be vulnerable to SM administered immediately after transfer.
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PASSIVE TRANSFER OF IMMUNITY TO TUBERCULOSIS BY MEANS OF CELLS FROM BCG VACCINATED MICE:II. Effects of Various Pretreatments of Cells to be Transferred

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