Passive Transfer of Immunity to Tuberculosis by Means of Cells from BCG vaccinated Mice:I. Comparison of Results obtained in Experiments with Two Mouse Strains different in the Suscep tibility to Tuberculosis

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Effects of transfers of peritoneal exudative or spleen cells from donor mice immunized with BCG upon the challenge infection of recipients with viru lent strains of M. tuberculosis were examined by means of quantitative cultivations of bacilli in the lungs and spleens.<BR>In dd strain mice transferred with immune perito neal cells from homologous dd mice, marked inhibi tory activity against bacterial multiplication was observed in the cultivated organs.<BR>However, the recipients of immune speen cells did not show so marked anti-microbial activity as observed in the recipients of immune peritoneal cells, although it was more obvious as compared with that of the controls.<BR>When inbred DK 1 strain mice which are more susceptible to infections with tubercle bacilli were transferred with peritoneal cells from immune iso logous or homologous donors, enhanced multipli cation of bacilli in organs of sacrificed mice, especially in an early phase of infections, was noticed.
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