:8. Trials of Airborne Infection of Mice with <I>Mycobacterium intracellulare</I> (The second report)
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概要
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The ddY conventional mice were infected aerogenically with a mouse virulent strain 31 F093T of <I>M. avium-intracellulare</I> (<I>M. intracellulare</I>), using TRI-R Airborn Infection Apparatus Model A42. The strain produced a 1, 000-fold increase in the number of viable mycobacteria recovered from lung, and a two-fold increase of lung weight after fifteen weeks of infection. The number of the viable bacilli was retained thereafter essentially on the same level with an ever increasing lung weight, which reached a 3-fold value at 28 weeks of infection. No deaths due to the infection ensued during the period of observation.<BR>Macroscopic lung lesions consisted of densely scattered small nodular lesions combined with dispersed grossly big nodules, which became visible at six weeks of infection. These lesions demonstrated histopathologically multiple granuloma formation at six weeks of in fection, and diffuse proliferative changes thereafter.<BR>The aerogenical pretreatment with an amorphous silica (Aerosil, Degussa, Frankfurt a.M. (FRG)) accelerated the disease, which was demonstrated macroscopically as well as micro scopically beyond nine weeks of infection. The pretreatment, however, could not change the disease process to an acute form.<BR>These chronic persistent lung infections in mice, which were aerogenically provoked by <I>M. intracellulare</I> 31F093T, have a few advantages as the models for experimental chemotherapy besides its being akin to the human infection in view of the route of infection. First, the infection procedure is much easier than intravenous and intraperitoneal infections in a large scale of experiment; second, a larger number of mice can be dealt with due to easier observations aimed only at the lung disease; third, various aerogenical pretreatments can be evaluated.
- 一般社団法人 日本結核病学会の論文
一般社団法人 日本結核病学会 | 論文
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