Mycobacterium fortuitum および Mycobacterium chelonae による肺感染症
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概要
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Nine cases of lung disease due to Mycobacterium fortuitum and four cases of lung disease due to <I>Mycobacterium</I> chelonae are reported. The clinical features of these diseases were described based on a total of 18 cases of <I>M. fortuitum</I> disease and of 14 cases of <I>M. chelonae</I> disease, including the cases reported previously. Slight differences were observed in the clinical feature of these diseases. The age of the patients with <I>M. chelonae</I> infection tended to be younger than that of the patients with <I>M. fortuitum</I> infection. In the roent genographic feature, the ratio of the primary infection-type against the secondary infection type was 1: 2 in the <I>M. fortuitum</I> disease, while that was 2: 1 in the <I>M. chelonae</I> disease. A close relationship between the roentgenographic feature and the prognosis was observed in the <I>M. fortuitum</I> disease. All 6 patients who showed the primary infection-type in the roentgenographic feature showed the negative conversion of sputum cultures. In contrast, the negative conversion was not easily obtained in patients with the secondary infection-type disease.<BR>Generally speaking, the prognosis of the diseases due to <I>M. fortuitum</I> and due to <I>M. chelonae</I> was good. Death due to progression of the disease was not observed. Two patients with the disease due to <I>M. fortuitum</I> died during the observation period, but of other causes.<BR>Until now, any effective agent for the diesases due to these organisms has not yet known. In the present study, we administered ofloxacin (DL 8280) at a dosis of 0.3g daily for 5 months to a patient with lung disease due to <I>M. fortuitum</I> (Table 2, Case no.1) and could obtain negative conversion of sputum cultures and improvement of roentgenographic feature (cavities became smaller).
- 一般社団法人 日本結核病学会の論文
一般社団法人 日本結核病学会 | 論文
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