Comparison of in vitro growth-inhibitory activities of ofloxacin, ciprofloxacin and norfloxacin against various species of Mycobacteria. Comparison of organ concentrations and blood concentrations in mice.:Comparison of Organ Concentrations and Blood Conc

概要

論文の詳細を見る
In vitro growth-inhibitory activities of three quinolones (ofloxacin, ciprofloxacin and norfloxacin) were compared against Mycobacterium tuberculosis, M. kansasii, M. avium complex, M. fortuitum, M. smegmatis, M. aurum, and M. phlei using the actual count method. The actual count method is a method measuring the minimal inhibitory concentration (or the resistance level) as the lowest concentration (or the highest cocnentration) on which small inocula consisting of 10 to 100 viable bacteria fail to grow (or can grow). The results showed that ofloxacin and ciprofloxacin are almost equally activie against the mycobacteria tested, but the activity of norfloxacin is 2 to 8 times lower than the former two. Ofloxacin tended to be more effective against most virulent Mycobacterium, M. tuberculosis, whereas ciprofloxacin tended to be somewhat more effective against nonpathogenic mycobacteria such as M. phlei and M. aurum. The organ concentrations and the blood concentrations of these agents in mice were compared after intraperitoneal injection of 1mg. The highest concentrations were obtained in norfloxacin, and secondly in ofloxacin. Ciprofloxacin showed the lowest levels.
一般社団法人日本結核病学会の論文