INH RFPを主軸とする化学療法の再排菌例の検討 - 国療化研第27次B 研究報告 -

概要

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89 cases of relapsed pulmonary tuberculosis were analyzed. These cases had been treated with INH and RFP for at least 6 months, originally sensitive to INH and RFP and with negative sputum cultures for at least 6 months after conversion. Relapsed cases were found regardless of: duration of previous chemotherapy if it was more than 6 months, duration of positive culture, amount of cultured bacilli, existence of cavities or character of their wall and whether sputum smears were positive or negative when cultures were negative in the previous treatment. The time of relapse was either early (within a year) or late after the complation of previous treatment. On the relapse from cases treated with initial short course chemotherapy, 55.5 per cent of cultured bacilli were resistant to INH and/or RFP. About half of the relapsed cases had complication ssuch as diabetes mellitus which was most common, pneumoconiosis or liver diseases.Upper respiratory tract infection or intemperate life might lead to relapse in some cases. Prognosis of relapsed cases was correlated with acquired drug resistance when relapsed. More than half of relapsed, cases were treated with previously used drugs. Majon changes of regimen was made only in a few cases.
一般社団法人日本結核病学会の論文