最近分離した百日咳菌とパラ百日咳菌の薬剤感受性

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Drug sensitivity of 67 strains of Bordetella pertussis and 10 strains of B. parapertussis isolated from patients in an outbreak of whooping cough in Miura Peninsula over a period from 1972 to 1973 was determined. It was compared with that of 25 strains of B. pertussis and 9 strains of B. parapertussis isolated over a period from 1952 to 1953 and preserved by lyophilization of subculture. The results obtained are summarized as follows.(1) The mean minimal inhibitory concentrations (MIC) against the 92 strains of B. pertussis ranged from ≤0.1 to 0.8units/ml for penicillin (PC), from ≤0.1 to 0.4mcg/ml for aminobenzylpenicillin (AB-PC), from 0.8 to 12.5mcg/ml for methyiphenylisoxazolylpenicillin (MPI-PC), from 12.5 to 100mcg/ml for cephalexin (CEX), from ≤0.1 to 3.1mcg/ml for sulfamonomethoxine (SA), from 0.2 to 3.1mcg/ml for streptomysin (SM), from ≤0.1 to 0.8mcg/ml for chioramphenicol (CP), from ≤0.1 to 0.2mcg/ml for tetracycline (TC), and from ≤0.1 to 3.1mcg/ml for nalidixic acid (NA).(2) The range MIC against the 19 strains of B. parapertussis were in the following: 6.3 to 50units/ml for PC, 0.8 to 3.1mcg/ml for AB-PC, ≥300mcg/ml for MPI-PC, 100 to 200mcg/ml for CEX, ≤0.1 to 1.6mcg/ml for SA, 25 to 100mcg/ml for SM, 0.4 to 0.8mcg/ml for CP, ≤0.1 to 0.4mcg/ml for TC, and 0.8 to 3.1mcg/ml for NA.(3) CEX, SA, CP, TC, and NA showed almost the same degrees of MIC against the 19 strains of B. parapertussis as against B. pertussis. PC, AB-PC, MPI-PC, and SM showed apparently different degrees of MIC against B. parapertussis from those against B. pertussis.(4) No drug-resistant strains were detected from the strains of B. pertussis or B. parapertussis isolated.(5) There was no difference in drug sensitivity between the recently isolated strains and the strains isolated about 20 years ago, regardless of the species.
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最近分離した百日咳菌とパラ百日咳菌の薬剤感受性

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