サルにおける赤痢菌感染実験について-5-

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On the experiments of Shigella infections, normal and pretreated animals were infected with multiple drug-resistant strains of Snigella flexneri 2a (Komatsu strain) or 3a (Miyata strain) by its introduction directly into the stomach.The pretreatments which the animal received were as follows.(1) Oral administration with CM and CaCO3 into the stomach.(2) Intravenous injection of sonicate (50mg, wet weighit).(3) Injection of sonicate (400mg, wet) into the duodenum.On the other experiments, the only sonicate of Shigella flexneri (26.7g, wet) or French press destroyed organisms (165mg, wet) were introduced directly into their stomach.The total animals used in these experiments were ten young monkeys weighing about 1kg.Number of live organisms introduced were 2.5×105∼2.4×108.The results were as follows.(1) The animal (M17) was injected directly with the sonicate (400mg, wet) into the duodenum. 5 hours later, it was introduced with living cultures of 6×106 into the stomach.This animal showed fatal changes. It was considerd that the symptom was more serious than dysentery(2) Symptoms of dysentery were not observed with the animal (M16) which is injected intraveously with sonicate (50mg, wet) and body temperature fell down from 38.9°C to 35.6°C within a few minutes after the injection.(3) Clinical changes were not observed with other animals.
日本細菌学会の論文