油脂に包埋せる抗酸性菌の菌力, 特に所謂非定型抗酸性菌えの一考察 : 第3編てんじくねずみ脂肪包埋菌の脳内ならびに肺内接種

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When guinea pigs were inoculated intracerebrally with M. phlei coated with fat extracted from guinea pigs, the severe lesion confusing with tuberculous ones were observed markedly on the brain or other visera, as in the case of intraperitoneal inoculation described in the previous paper.<BR>The guinea pigs inoculated with the fat-coated M. phlei in the route of intracerebra died within 10 days after infection in the dosis of 0.1mg, although the guinea pigs injected with the water-suspended M. phlei remained alive for a period of 16 days.<BR>Numerous bacilli used were possible to detect from the brain or other viscera in the “fat-coated” Group, while none in the “water-suspended” Group.<BR>Furthermore, the fat-coated M. phlei gave, also intrapulmonally, the severe lesions, and the longerterm remaining of bacilli in guinea pigs.<BR>From the avove, it is considered to be a certain fact that the non-pathogenic acidfast bacteria are possible to obtain some pathogenicity in the case of fat-coating.
日本細菌学会の論文