野兎病菌の実験動物に対する研究補遺 : VII. モルモツトについての免疫実験

概要

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Guinea pigs were conferred immunity by the inoculation of Bacterium tularense vaccines. The degree of protection thus conferred on the animals was higher in the case of the vaccines made from living organisms than those made from killed culture. The immunized animals survived the challenge with the organisms and the pathological changes caused by the challenge were found slight in every aspect as compared with those of control animals, When the immunized animals were challenged with highly virulent strain, the agglutinin titers having been produced in the animals declined once, but they tended to increase again several days later, showing the evidence that the animals which recovered the rise in the agglutinin titers could survive and those which failed to do so were brought to death. It seems that the agglutinin has some relation to the degree of animal protection but had no protective properties against Bacterium tularense.
日本細菌学会の論文