Effects of Hesperidin on the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats
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概要
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The protective effects of hesperidin against hypercholesterolemia and fatty liver were examined in male Wistar rats fed a high-cholesterol diet for 12 weeks. Compared with a standard diet, a high-cholesterol diet not only increased body weights, liver weights, and serum concentration of cholesterol, but also induced the fatty degeneration (steatosis) of liver. Hesperidin (0.08%) reduced levels of hepatic steatosis, adipose tissue and liver weights (P < 0.05), serum total cholesterol and retinol binding protein (RBP) 4 concentrations (P < 0.05) in rats fed with high-cholesterol diet, while reduction in low-density lipoprotein cholesterol levels and triglyceride concentrations was not significant. It also attenuated the marked changes in mRNA expression of lipid metabolism–related proteins: RBP, heart fatty acid–binding protein (H-FABP), and cutaneous fatty acid–binding protein (C-FABP), in liver and adipose tissue. According to the results of gas chromatography, serum concentrations of total cholesterol and biomarkers of cholesterol synthesis (lathosterol) and absorption (campesterol, β-sitosterol) were lower, and concentrations of cholesterol in feces were higher in the rats given hesperidin (P < 0.05). Hesperidin may improve hypercholesterolemia and fatty liver by inhibiting both the synthesis and absorption of cholesterol and regulating the expression of mRNA for RBP, C-FABP, and H-FABP.
著者
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Hasegawa Junichi
Division Of Pharmacotherapeutics Department Of Pathophysiological And Therapeutic Science Faculty Of
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Matsuda Akiko
Division Of Functional Diagnostic Science Osaka University Graduate School Of Medicine
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Miura Norimasa
Division Of Pharmacotherapeutics Department Of Pathophysiological And Therapeutic Science Faculty Of
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Kimura Koji
Division Of Functional Radiation Science Research Center For Bioscience And Technology Tottori Unive
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Wang Xinhui
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty
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Kitamura Yoshiyuki
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty
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Wang Zhongzhi
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty
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Shinoda Waka
Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty
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- Effects of Hesperidin on the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats
- Effects of Hesperidin on the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats