DECOMPOSITION OF α-TOCOPHERYL SPIRODIMER BY ALKALINE SAPONIFICATION

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概要

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• An alkaline saponification method containing pyrogallol is usually applied for the determination of tocopherols. Although there are some metabolites of α-tocopherol in tissues, it is not yet clear whether they are true metabolites or degradation products from the alkaline saponi-fication. Since it was shown that α-tocopheryl spirodimer, a metabolite of α-tocopherol, was degraded mainly to a substance positive to Emmerie-Engel reagent, the identification of this substance was carried out. As the model compound of α-tocopherol (α-T), mainly 2, 2, 5, 7, 8-penta-methyl-6-hydroxy-chromane (M) was used. The results obtained showed that spirodimers of α-T and M were reduced to the corresponding di-hydroxydimers with pyrogallol during the saponification. Therefore, it was suggested that the alkaline saponification method could not be applied to detect the metabolites from α-T and related compounds.

• 財団法人 学会誌刊行センターの論文

著者

• 五十嵐 脩

  Research Institute of Food Chemistry, Ochanomizu University

• 萩野 美恵子

  Research Institute of Food Chemistry, Ochanomizu University

• 稲垣 長典

  Research Institute of Food Chemistry, Ochanomizu University

関連論文

• OXIDATION PRODUCTS OF N-METHYL-2, 2, 7, 8-TETRAMETHYL-6-AMINO-CHROMAN, A MODEL COMPOUND OF N-METHYL-γ-TOCOPHER-AMINE WITH POTASSIUM FERRICYANIDE
• DECOMPOSITION OF α-TOCOPHERYL SPIRODIMER BY ALKALINE SAPONIFICATION
• REACTIVITY OF α-TOCOPHEROL WITH HYDRO-PEROXIDE OF METHYL LINOLEATE

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