EFFECT OF AMINO ACID SUPPLEMENT ON LIVER LIPID CONTENT AND LIPID METABOLISM OF RATS FED A NONPROTEIN DIET

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概要

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• The accumulation of lipid in the liver was observed in rats fed a non-protein diet supplemented with methionine, but further supplement of threonine partially prevented liver lipid accumulation. Supplements of leucine, phenylalanine or histidine slightly lowered the liver lipid accumulation of rats fed the nonprotein diet containing methionine. On the other hand, free fatty acid in the plasma was not changed when rats were fed the nonprotein diet supplemented with methionine. No difference Was observed in the plasma lipoprotein of rats fed a non-protein diet supplemented with or without methionine. However, the threonine supplement increased the total esterified fatty acid in the plasma lipoprotein (d<1.006) of rats fed a nonprotein diet containing methionine. A slight decrease was observed in the β-lipoprotein of rats fed the nonprotein diet supplemented with methionine. When injected with Triton WR-1339, the total esterified fatty acid content remarkably increased in the plasma of rats fed the nonprotein diet supplemented with methionine as well as the nonprotein diet, and the plasma β-lipoprotein of Triton WR-1339 treated rats was also increased in both groups. Therefore, it was assumed from the results that the transport of lipid from liver into blood is not inhibited in this type of fatty liver. At present, the cause of the fatty liver due to methionine supplementation to a nonprotein diet is not clear. However it seems un-likely that the inhibition of the lipoprotein transport from the liver to the blood plasma is the main reason for it.

• 財団法人 学会誌刊行センターの論文

著者

• 吉田 昭

  Department Of Biochemical Genetics City Of Hope Research Institute

• 細谷 徳治

  Department of Nutrition, Kobe-Gakuin University

• 吉田 昭

  Department of Agricultural Chemistry, Nagoya University

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