Breaking action of reductones related to ascorbic acid on nucleic acids.

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概要

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• The action of two types of ascorbate-related reductones on nucleic acids was investigated by comparison with that of ascorbic acid (AsA). Amino reductone (ScA) and thiol reductone (MHC) caused strandscissions in nucleic acids. This was confirmed by the fact that reductones lowered the viscosity of DNA solution and shifted the peaks of DNA and RNA to the low molecular side in centrifugal profile. Cue2+ strengthened their action as in the case of enediol reductones. The breaking activity of thiol reductone is relatively weak compared with those of amino and enediol reductones, The preferential degradation of apurinic acid was caused with amino and thiol reductones, suggesting that pyrimidine clusters in nucleic acids were susceptible to breakage.

• 財団法人 学会誌刊行センターの論文

著者

• 大村 浩久

  Food Chemistry Institute, Department of Food Science and Technology, Kyushu University

• 大村 浩久

  Food Chemistry Institute, Faculty of Agriculture, Kyushu University

• 富田 純史

  Department of Public Healthg School of Medicine, Kurume University

• 藤木 博明

  Food Chemistry Institute, Faculty of Agriculture, Kyushu University

• 篠原 和毅

  Food Chemistry Institute, Faculty of Agriculture, Kyushu University

• 村上 浩紀

  Food Chemistry Institute, Faculty of Agriculture, Kyushu University

関連論文

• EFFECT OF REDUCTONES ON GLYOXALASE I
• Breaking action of reductones related to ascorbic acid on nucleic acids.
• Studies on the physiological function of reductones. XVI. Breaking action of ascorbic acid on nucleic acids.

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