Antagonism of L(-)pantothenic acid on lipid metabolism in animals.

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The inhibition rate of L (-) pantothenate as an antagonist of D (+) pantothenate was discussed from the viewpoint of growth and lipid metabolism. The growth rate of mice given pantothenate-deficient diets containing L (-) pantothenate (300 mg per 100 g diet) was markedly decreased, and such pantothenate-deficient symptoms as "spectacle eyes" appeared. However, it was recovered by the simultaneous addition of D (+)pantothenate. This result suggests that L (-) pantothenate is an antagonist of D (+) pantothenate. The same phenomenon was observed in a rat experiment. The growth of rats given L (-) pantothenate was extremely poor but recovered by the simultaneous addition of D (+) pantothenate. Its complete recovery was seen when the ratio of L (-) pantothenate to D (+) pantothenate reached 100:1. The same tendencies were observed in the liver levels of total lipid, total cholesterol and triglyceride, and also in the lipoperoxide values. This experiment suggests that the inhibition rate of L (-) pantothenate to D (+)pantothenate in animals is similar to that of DL-ω-methyl pantothenate.
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