Mechanisms of Adverse Effect of Amaranth Feeding in the Rat
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概要
- 論文の詳細を見る
In order to clarify the mechanism of the adverse effects of dietary amaranth, trisodium 1-(4-sulfo-l-naphthylazo)-2-naphthyl-3, 6 disulfonic acid, the effects of amaranth in vitro and in a jejunum perfusion in vivo on intestinal sucrase were investigated in rats. The inhibitory effect of amaranth in vitro on the sucrase activity was not detected even at the concentration of 1%, whereas the remarkable release of intestinal sucrase from intestine was observed with the jejunum perfusion of Ringer bicarbonate solution (RBS) containing amaranth at the 1% level. On the other hand, the perfusion of RBS containing tris(hydroxymethyl)aminomethane, a strong inhibitor of intestinal disaccharidase activities, did not produce the release of intestinal alkaline phosphatase. These findings suggest that the toxicity of dietary amaranth is due to the exfoliating or solubilizing effects of amaranth on the brush border membrane of the small intestine.
- 財団法人 学会誌刊行センターの論文
著者
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木村 利三
Laboratory of Nutritional Biochemistry, Department of Agriculture Chemistry, Nagoya University
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長谷川 和富
Laboratory of Nutritional Biochemistry, Department of Agriculture Chemistry, Nagoya University
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今村 仁美
Laboratory of Nutritional Biochemistry, Department of Agriculture Chemistry, Nagoya University
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吉田 昭
Laboratory of Nutritional Biochemistry, Department of Agriculture Chemistry, Nagoya University
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吉田 昭
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University
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木村 利三
Laboratory of Food and Nutrition, Department of Home Economics, Osaka Kyoiku University
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