Effects of Dietary Ethanol on Ascorbic Acid and Lipid Metabolism, and Liver Drug-Metabolizing Enzymes in Rats
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概要
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Effects of dietary ethanol on ascorbic acid and lipid metabolism, and liver drug-metabolizing enzymes in rats fed a semi-purified diet containing a powdered ethanol preparation (30 cal% in the diet) were studied. Administration of ethanol increased urinary ascorbic acid excretion (p<0.001) and ascorbic acid level in the liver (p<0.001) and the spleen (p<0.01). The activity of hepatic aniline hydroxylase was increased (p<0.05) by ethanol feeding but that of aminopyrine Ndemethylase was not. Increases of serum total and high-density-lipoprotein (HDL) cholesterol level, commonly observed by the administration of xenobiotics, were not observed. These results showed ethanol possessed rather similar properties to xenobiotics such as polychlorinated biphenyls (PCB) or 1, 1, 1-trichloro-2, 2-bis(p-chlorophenyl)ethane (DDT) in some metabolic changes. In this study, no accumulation of lipid in the liver was observed. Key Fords ethanol, ascorbic acid, drug-metabolizing enzymes, cholesterol, liver lipids
著者
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吉田 昭
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University
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望月 聡
Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University
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