Menaquinone (Vitamin K2)-6 Production by Mutants of Flavobacterium meningosepticum

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概要

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• Flavobacterium meningosepticum IFO 12535, a mena quinone (MK) producer, was mutagenized to improve productivity. A mutant, which was resistant to 1-hydroxy-2-naphthoate (HNA), was found to produce MK more abundantly: 34mg/liter of culture broth and 5.5mg/g of dry cells. The mutant was less sensitive to inhibition by HNA on MK biosynthesis than the wild-type strain. MK was isolated from cells of the mutant and identified as MK-6 based on its physicochemical characteristics. Mutants, which were given each KCN resistance, aromatic amino acid auxotrophy and no carotenoid productivity, did not show further increase of productivity.

著者

• 山田 秀明

  Department of Agricultural Chemistry, Kyoto University

• 谷 吉樹

  Research Center for Cell and Tissue Culture

• 朝日 知

  Department fo Agricultural Chemistry, Kyoto University

関連論文

• Menaquinone (Vitamin K2)-6 Production by Mutants of Flavobacterium meningosepticum
• Properties of Pyridoxine Glucoside
• Vitamin B6 biosynthesis and glycolate reductase in Flavobacterium sp. 238-7.
• Reinvestigation of compounds X, a suspected biotin intermediate: Identification of N-formyl derivatives of biotin and dethiobiotin.

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