Reinvestigation of compounds X, a suspected biotin intermediate: Identification of N-formyl derivatives of biotin and dethiobiotin.

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概要

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• Compound X, reported as an intermediate in the biosyn-thesis of biotin from dethiobiotin (DTB) (Biochem. Biophys. Res. Commun., 88, 312 (1979)), was found to contain N-formyl DTB and biotin. The methyl ester of N-formyl biotin was considered to be a product from the biotin, which was biosynthesized from DTB by resting cells of E. coli C 124, through treatment with diazomethane in the presence of a trace amount of formic acid after Dowex 1X2 column chromatography. NMR analysis revealed that biotin was formylated at 1'-N. N-Formylated DTB and biotin are new biotin derivatives.

• 財団法人 学会誌刊行センターの論文

著者

• 山田 秀明

  Department of Agricultural Chemistry, Kyoto University

• 和泉 好計

  Department of Agricultural Chemistry, Kyoto University

• 田村 光司

  Department of Agricultural Chemistry, Kyoto University

• 大堺 美弥子

  Department of Agricultural Chemistry, Kyoto University

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• Reinvestigation of compounds X, a suspected biotin intermediate: Identification of N-formyl derivatives of biotin and dethiobiotin.

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