Thermotropic interaction of vitamin E with dimyristoyl and dipalmitoyl phosphatidylcholine liposomes.

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概要

• 論文の詳細を見る

• The effect of vitamin E on the thermal behavior of two saturated phosphatidylcholines was investigated by differential scanning calorimetry. For dimyristoyl and dipalmitoyl phosphatidylcholines, the addition of vitamin E at concentrations of 1, 5 and 10 mol% vitamin E, resulted in a lowering of the phase transition temperature and a broaden-ing of the temperature range of the phase transition indicating an increase in the fluidity of the phospholipids. Taken together with other physical studies on the effect of vitamin E on (unsaturated) phospholipids, these results indicate that vitamin E could influence the physical properties of membrane phospholipids in addition to its known antioxidant role. The likelihood of this interaction would be enhanced if vitamin E was not randomly distributed in biological membranes but rather was located in domains where its local concentration, relative to phospholipids, was elevated.

• 財団法人 学会誌刊行センターの論文

著者

• MCINTOSH Graeme

  CSIRO Division of Human Nutrition

• MCMURCHIE Edward

  CSIRO Division of Human Nutrition, Glenthorne Laboratory

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• Thermotropic interaction of vitamin E with dimyristoyl and dipalmitoyl phosphatidylcholine liposomes.

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