Effect of Mg deficiency on blood pressure in rats treated with cadmium.

スポンサーリンク

概要

• 論文の詳細を見る

• Forty male STD-Wistar rats, weighing about 210g on the average, were divided into two dietary groups. These were, further subdivided into the following eight groups: 1) control rats fed the normal diet (N rats: group #1), N rats treated with 0.1mg Cd (group #2), 0.5mg Cd (group #3), and 1.0mg Cd (group 114); 2)mg-deficient rats (D rats: group #5), D rats treated with 0.1mg Cd (group #6), 0.5mg Cd (group #7), and 1.0mg Cd (group #8). Before Cd treatment the rats were given the normal diet or themg-deficient diet for 14 consecutive days (day -14). Subcutaneous injection of 0.1 ml of cadmium chloride (CdCl2) in the backs of the animals given a normal diet or amg-deficient diet at the three doses of 0.1, 0.5, and 1.0mg/kg body was performed twice a day (12h intervals) (time-zero) for 7 consecutive days and then these animals were maintained without Cd treatment for an additional period of 20 days (+28 days). Body weight gain inmg-deficient rats (D rats) was significantly decreased. The effects of Cd treatment in the rats fed the normal diet (N rats) were also significant.mg deficiency enhanced the decreased body weight gain in D rats treated with Cd on day 24 though no enhancement of the decreased food consumption in those rats was observed.mg deficiency lowered the blood pressure in rats and this response was more pronounced in D rats treated with Cd. The increased urinary Na excretion and the decreased water retention were not observed in the D rats; this response was not pronounced in the D rats treated with Cd. These results suggest that an enhancement of the decreased blood pressure in Cd-treated rats by themg deficiency is not responsible for the decreased water retention. Ca concentration in the heart and aorta of D rats was within the same range as that of N rats.mg deficiency increased Ca concentration in the heart and aorta of the D rats treated with 0.5 and 1.0mg Cd though Cd itself did not affect the Ca and ATP concentrations, Ca andmg balance (Ca/Mg), and heart weight in the heart of N rats. These results suggest thatmg deficiency may increase the overload of Ca in the heart and aorta of D rats treated with Cd, which may in turn lead to enhancement of the Cd-induced cardiotoxic effects. The decrease in urinary total Ca and Cd excretion of D rats treated with Cd may result from the increased Ca and Cd concentrations in body burden, Enhancement of Cd-Induced cardiotoxic effectes bymg deficiency may be factors for the pronounced lower blood pressure in D rats treated with Cd.

• 財団法人 学会誌刊行センターの論文

著者

• 斉藤 昇

  Department of Animal Science, Faculty of Agriculture, Nagoya University.

• 西山 省二

  Department of Environmental and Occupational Health Kochi Medical School

• 小西 裕子

  Department of Medical Research Center, Kochi Medical School

関連論文

• 鶏の体脂肪蓄積に及ぼす分離大豆タンパク質及びカゼインの影響
• Concentration of Metallothionein in Human Pancreas
• Cardiotoxicity in magnesium-deficient rats fed cadmium.
• Effect of Mg deficiency on blood pressure in rats treated with cadmium.

スポンサーリンク