Changes in Rat Alveolar Macrophageal Antioxidant Defense and Reactive Oxygen Species Release by High Dietary Vitamin E

スポンサーリンク

概要

• 論文の詳細を見る

• For the past decade there has been emphasis on the immunomodulatory effects of vitamin E apart from its established role as a free radical scavenger. In alveolar macrophages (AMs), the role of vitamin E supplementation has not yet been investigated sufficiently. In the present study we have evaluated the effects of high vitamin E (DL-α-tocopheryl acetate, α-TA) supplementation for 10 d on rat-alveolar macrophageal antioxidant defense and reactive oxygen species (ROS) release. There was an increase in plasma vitamin E content from 5.22±1.30, at 50mg to 12.23±1.06 and 22.32±2.02μg/mL at 250 and 1, 250mg α-TA/kg dietary supplementation. Alveolar macrophage-vitamin E content enhanced by 56 to 75% at 250 and 1, 250mg α-TA diet as compared with control diet. Superoxide dismutase activity decreased and catalase and glutathione peroxidase activities increased significantly in AMs of 250 and 1, 250mg α-TA diet-fed rats. Reduced glutathione, total glutathione, and glutathione-S-transferase activity in AMs did not change significantly at any of the high doses of α-TA supplementation. On stimulation of AMs by phorbol-12-myristate-13-acetate (PMA), there was 2.8 and 3.5-fold enhancement in superoxide (O2_??_) and H2O2 production, respectively, at 50mg α-TA dose. But this increase by PMA could not take place in AMs from animals supplemented with 250 and 1, 250mg α-TA. It may therefore be concluded that high a-TA supplementation in diet may equip the AMs with a stronger defense against oxygen-free radical mediated damage to them.

• 財団法人 学会誌刊行センターの論文

著者

• Syal Nidhi

  インド

• Pathak Chander

  Departments Of Biophysics Postgraduate Institute Of Medical Education And Research

• Syal Nidhi

  Department Of Biophysics Postgraduate Institute Of Medical Education And Research

• Pathania Vandana

  Department Of Biophysics Postgraduate Institute Of Medical Education And Research

• Khanduja Krishan

  Department Of Biophysics Postgraduate Institute Of Medical Education And Research

• Pathak Chander

  Department Of Nuclear Medicine Postgraduate Institute Of Medical Education And Research

• PATHAK Chander

  Department of Biophysics, Postgraduate Institute of Medical Education

• SYAL Nidhi

  Department of Biophysics, Postgraduate Institute of Medical Education

• KHANDUJA Krishan

  Department of Biophysics, Postgraduate Institute of Medical Education

• PATHANIA Vandana

  Department of Biophysics, Postgraduate Institute of Medical Education

関連論文

• Resveratrol Inhibits N-nitrosodiethylamine-Induced Ornithine Decarboxylase and Cyclooxygenase in Mice
• Vitamin E Suppresses the Induction of Reactive Oxygen Species Release by Lipopolysaccharide, Interleukin-1β and Tumor Necrosis Factor-α in Rat Alveolar Macrophages
• Changes in Rat Alveolar Macrophageal Antioxidant Defense and Reactive Oxygen Species Release by High Dietary Vitamin E
• Evaluation of the Predictors of Choledocholithiasis : Comparative Analysis of Clinical, Biochemical, Radiological, Radionuclear, and Intraoperative Parameters
• Whole Body Exposure to Low-dose Gamma Radiation Promotes Kidney Antioxidant Status in Balb/c Mice
• Gallic Acid, an Antioxidant, Exhibits Antiapoptotic Potential in Normal Human Lymphocytes : A Bcl-2 Independent Mechanism
• Changes in Rat Alveolar Macrophageal Antioxidant Defense and Reactive Oxygen Species Release by High Dietary Vitamin E

スポンサーリンク