Gallic Acid, an Antioxidant, Exhibits Antiapoptotic Potential in Normal Human Lymphocytes : A Bcl-2 Independent Mechanism
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概要
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Oxidative stress, produced as a consequence of normal metabolism or induced by extraneous stimuli, has been proved to be a mediator of cell death. The inherent antioxidant defense system and exogenous antioxidants can help the body to combat this oxidative stress-induced cell death. In this study, we explored the antiapoptotic potential of gallic acid, a dietary phenolic having antioxidative and anticarcinogenic properties, in normal human peripheral blood lymphocytes (PBLs). Incubation of PBLs with 100μM H2O2 for 1.5-2.0 h induced phosphatidyl serine externalisation, lipid peroxidation and high molecular weight DNA fragmentation. Pretreatment of lymphocytes with gallic acid for 18 h could effectively inhibit lipid peroxidation and apoptosis induced by oxidative stress. Treatment of PBLs with gallic acid failed to induce any change in the expression of Bcl-2, an antiapoptotic protein. It seems that the protection provided by gallic acid was due to its direct action in the scavenging of free radicals as it was found to be a stronger antiradical than trolox, a water- sol-uble analogue of vitamin E.
- 財団法人 学会誌刊行センターの論文
- 2003-08-01
著者
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KHANDUJA Krishan
Department of Biophysics, Postgraduate Institute of Medical Education and Research
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Khanduja Krishan
Department Of Biophysics Postgraduate Institute Of Medical Education And Research
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SOHI Kiranjit
Department of Biophysics, Postgraduate Institute of Medical Education and Research
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MITTAL Nidhi
Department of Biophysics, Postgraduate Institute of Medical Education and Research
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HUNDAL Manjinder
Department of Pharmaceutical Sciences, Texas Technological University and Health Sciences Center
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Mittal Nidhi
Department Of Biophysics Postgraduate Institute Of Medical Education And Research
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Hundal Manjinder
Department Of Pharmaceutical Sciences Texas Technological University And Health Sciences Center
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Sohi Kiranjit
Department Of Biophysics Postgraduate Institute Of Medical Education And Research
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- Whole Body Exposure to Low-dose Gamma Radiation Promotes Kidney Antioxidant Status in Balb/c Mice
- Gallic Acid, an Antioxidant, Exhibits Antiapoptotic Potential in Normal Human Lymphocytes : A Bcl-2 Independent Mechanism
- Changes in Rat Alveolar Macrophageal Antioxidant Defense and Reactive Oxygen Species Release by High Dietary Vitamin E