Effect of Feeding Clofibrate-Containing Diet on the Hepatic NAD+ Level in Rats.

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概要

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• Feeding rats with a diet containing 0.25% clofibrate for 2 weeks elevated the hepatic NAD+ and total nicotinate levels significantly. Other peroxisome proliferators, such as 2-(4-chlorophenoxy)propionic acid and di(2-ethylhexyl)phthalate, had similar effects. When rats were fed the control diet without clofibrate for 1 week after 2 weeks of the clofibrate diet, the hepatic NAD+ level returned to the control value. Muscular NAD+ content was not affected by the peroxisome pro-liferators. The results were discussed in relation to induction of peroxi-somal β-oxidation enzymes by the peroxisome proliferators.

• 財団法人 学会誌刊行センターの論文

著者

• Umezawa Chisae

  School Of Pharmacy Kobe Gakuin University

• UMEZAWA Chisae

  School of Pharmacy, Kobe Gakuin University

• LOO Yee

  School of Pharmacy, Kobe Gakuin University

• SHIN Mariko

  School of Pharmacy, Kobe Gakuin University

• YAMASHITA Yuka

  School of Pharmacy, Kobe Gakuin University

• ISHIGAMI Mayumi

  School of Pharmacy, Kobe Gakuin University

• SASAKI Mie

  School of Pharmacy, Kobe Gakuin University

• SANO Keiji

  School of Pharmacy, Kobe Gakuin University

関連論文

• Role of Glucose Dehydrogenase and Glucose Catabolism in Triggering of Spore Germination in Bacillus subtilis
• Increased Conversion Ratio of Tryptophan to Niacin by the Administration of Clofibrate, a Hypolipidemic Drug, to Rats
• Effect of Feeding Clofibrate-Containing Diet on the Hepatic NAD+ Level in Rats.
• Metabolism of Tryptophan to Niacin in Saccharomyces uvarum.
• Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma : analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

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