Absorption and Metabolism of Pyridoxamine in Mice. I.Pyridoxal as the Only Form of Transport in Blood.
スポンサーリンク
概要
- 論文の詳細を見る
[3H] Pyridoxamine was orally administered to mice in physiological amounts, and the distribution of isotope between the six recognized forms of vitamin B6 and pyridoxac acid was determined at different times in the intestine, liver, blood, and brain. After 7 min about 50% of the radioactivity in pyridoxamine had been absorbed by the intestine and transported to the blood and other organs. Labeled pyridoxal phosphate was found in the intestine and liver. Labeled pyridoxamine could not be detected in the peripheral blood, but substantial amounts of labeled pyridoxal and pyridoxal phosphate were found in the blood. However, when a large amount (40-140 nmol) was given, a significant amount of labeled pyridoxamine was found in the blood, together with labeled pyridoxal and pyridoxal phosphate. These results suggest that the intestine and/or liver play a major role in completely converting physiological amounts of pyridoxamine to circulating pyridoxal, which is then taken up and phosphorylated by other organs.
- 財団法人 学会誌刊行センターの論文
著者
-
Mizuno Aritake
Department Of Biochemistry The Jikei University School Of Medicine
-
Asakura Tadashi
Department Of Obstetrics And Gynecology Nippon Medical School
-
SAKURAI Tae
Department of Biochemistry, The Jikei University School of Medicine
-
MATSUDA MAKOTO
Department of Biochemistry, Jikei-University School of Medicine
関連論文
- In-beam γ-ray spectroscopy of neutron-rich ^Pu and properties of N=152 deformed shell closure(International Workshop on Nuclear Structure-New Pictures in the Extended Isospin Space(NS07)-)
- Ground-State Band of the Neutron-Rich Transuranium Nucleus ^Cm_(Nuclear Physics)
- Immunohistochemical Study of Calpain-Mediated α-Crystallin Proteolysis in the UPL Rat Hereditary Cataract
- LENS DEVELOPMENT AND CRYSTALLIN DISTRIBUTION OF THE EARLY ONSET HEREDITARY CATARACT IN THE UPL RAT
- Changes of Secondary Structure Detected by Laser Raman Spectroscopy in Model Peptides of Human αA-Crystallin Due to Substitution of D-Aspartyl Residues for L-Aspartyl Residues
- P1-IS-19 PR, ssDNA and Ki67 antigen, the better immunohistochemical predictors of hormonal response in the biopsy specimens of endometrial adenocarcinoma during the high dose progestin therapy?
- 15-31.Placental alkaline phosphotase versus human chorionic gonadotropin as an efficient immunohistochemical marker to identify chorionic villous structures with degeneration (Session 17 Perinatology 6)
- ALTERATION OF LENS SULFHYDRYL GROUPS INDUCED BY OXIDATIVE STRESS : RAMAN SPECTROSCOPIC STUDY OF HYDROGEN PEROXIDE-TREATED RAT LENS
- Mitotic index versus apoptotic index in biopsies as predictor of response to high-dose progesterone therapy for endometrial adenocarcinoma(Oncology 11)
- EFFECT OF PYRIDOXAL PHOSPHATE DEFICIENCY ON AROMATIC L-AMINO ACID DECARBOXYLASE ACTIVITY WITH L-DOPA AND L-5-HYDROXYTRYPTOPHAN AS SUBSTRATES IN RATS
- DIFFERENCES BETWEEN THE TRANSAMINASES IN MITOCHONDRIA AND SOLUBLE FRACTION:I. GLUTAMIC-PYRUVIC TRANSAMINASE
- Absorption and Metabolism of Pyridoxamine in Mice. I.Pyridoxal as the Only Form of Transport in Blood.