Marginal Zinc Deficiency and Changes in Behavioral Salt Taste Threshold and Salt Preference in Mice.

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概要

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• An animal model of marginal zinc deficiency was tested in mice, and salt taste threshold and salt preference were investigated in the state of marginal zinc deficiency. Two experiments were conducted. In Experiment 1, four-week-old male ICR mice were fed diets of three different levels of zinc content (3.17, 9.27, or. 48.13μg Zn/g) for 60 days. Food intake, growth, zinc levels in tissues, hepatic metallothionein (MT) content, and activities of selected enzymes (hepatic and RBC δ-amino-levulinic acid dehydratase (ALAD) and plasma alkaline phosphatase (ALP)) did not differ among the groups throughout the experiment, and no overt signs of zinc deficiency were manifested in any group. In Experiment 2, four-week-old male ICR mice were fed a zinc-deficient diet (1.98μg Zn/g) or a zinc-adequate diet (49.14μg Zn/g) for 56 days. Food intake and growth did not differ between the two groups, and no overt signs of zinc deficiency were observed throughout the experiment. Zinc levels in the plasma and femur-but not those in the brain, kidneys, liver, and red blood cell (RBC)-and plasma ALP activities were significantly lower on Day 42 and Day 56 of the experiment in the mice fed the zinc-deficient diet (ZnD group) than in those fed the zinc-adequate diet (ZnA group). Hepatic MT contents were lower in the ZnD group than in the ZnA group on Day 56 only. Salt taste threshold was 0.05% in the ZnA group, while it was 0.1% in the ZnD group, between Day 30 and Day 38, and between Day 44 and Day 52 of the experiment. Preference for 0.9% NaCl solution was no different in the two groups when tested between Day 38 and Day 40 or between Day 52 and Day 54, but that for 1.6% NaCl solution was significantly higher in the ZnD group than in the ZnA group between Day 40 and Day 42, and between Day 54 and Day 56.

• 財団法人 学会誌刊行センターの論文

著者

• Okazaki Yoichi

  Department Of Radiology Nagano Red Cross Hospital

• Dejima Yasushi

  Department Of Human Ecology School Of Health Sciences Faculty Of Heath Sciences Kyorin University

• Suzuki Tsuguyoshi

  Department Of Human Ecology School Of Health Sciences Faculty Of Medicine University Of Tokyo

• LIU Xing-Wang

  Department of Human Ecology, School of Health Sciences, Faculty of Medicine, The University of Tokyo

• SUZUKI Tsuguyoshi

  Department of Human Ecology, School of Health Sciences, Faculty of Medicine, The University of Tokyo

• HIMENO Sei-ichiro

  Department of Human Ecology, School of Health Sciences, Faculty of Medicine, The University of Tokyo

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