Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome.

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概要

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• The antioxidant activities of ubiquinol and ubiquinone were measured in the free radical-mediated oxidations of methyl linoleate in solution and phosphatidylcholine liposomes in aqueous dispersion. Ubiquinol-10 suppressed the oxidation of methyl linoleate in hexane, although its reactivity toward peroxyl radical was about 10 times less than that of a tocopherol. Ubgquinone-10, on the contrary, did not show any antioxidant activity. On the other hand, Ubiquinol-10 inhibited the oxidation of phosphatidylcholine liposomal membranes as efficiently as α-tocopherol. When both ubiquinol-10 and α-tocopherol were present, ubiquinol-10 decreased first and α-tocopherol decreased after all ubiq-uinol-10 was consumed in both solution and liposomes. These results and electron spin resonance (ESR) study suggest that ubiquinol-10 regenerates α-tocopherol by reducing α-tocopheroxyl radical.

• 財団法人 学会誌刊行センターの論文

著者

• 二木 鋭雄

  Department of Reaction Chemistry, aculty of Engineering, University of Tokyo

• 山本 順寛

  Department of Reaction Chemistry, Faculty of Engineering, University of Tokyo

• 小室 絵里佳

  Department of Reaction Chemistry, Faculty of Engineering, University of Tokyo

関連論文

• Action of Vitamin E as Antioxidant in Phospholipid Liposomal Membranes as Studied by Spin Label Technique
• Free Radical Chain Oxidation and Hemolysis of Erythrocytes by Molecular Oxygen and Their Inhibition by Vitamin E
• Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome.
• Free radical-mediated damage of blood and its inhibition by antioxidants.

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